Universidade Federal Do Rio Grande Do Norte

............................................................................................................................ 3 RESUMO .................................................................................................................................. 4 RÉSUMÉ ................................................................................................................................... 5 AGRADECIMENTOS ............................................................................................................ 8 ACKNOWLEDGEMENTS .................................................................................................. 10 TABLE OS CONTENTS ...................................................................................................... 12 TABLE OF FIGURES .......................................................................................................... 13 LIST OF TABLES ................................................................................................................. 15 GENERAL INTRODUCTION ............................................................................................ 16 Targeted drug delivery ..... .................................................................................................... 16 Nanotechnological delivery systems ..................................................................................... 18 Polymeric microparticles ..................................................................................................... 20 Lipid-based systems ............................................................................................................. 21 SECTION I: POLYMERIC MICROPARTICLES ........................................................... 26 Chapter I: Book chapter “Xylan, a promising hemicellulose for pharmaceutical use” ...... 27 Chapter II: Article 1 “Xylan from corn cobs, a promising polymer for drug delivery: Production and characterization” ......................................................................................... 54 Chapter III: Article 2 “Influence of the lipophilic external phase composition on the preparation and characterization of xylan microcapsules: A technical note” ...................... 62 Chapter IV: Article 3 “Producing hemicellulose-based microparticles using chemical and physico-mechanical approaches as carriers for 5-aminosalicylic acid” .............................. 68 SECTION II: AMB-LOADED MICROEMULSIONS ....................................................... 91 Chapter V: Article 4 “Challenges and recent advances on the delivery of poorly soluble drugs: An update on the development of carriers for amphotericin B” ............................... 92 Chapter VI: Article 5 “Development and characterization of oil-in-water microemulsions for the oral delivery of amphotericin B” ............................................................................ 122 GENERAL DISCUSSION ................................................................................................... 143 CONCLUSIONS ................................................................................................................... 151 REFERENCES .................................................................................................................... 154 te l-0 08 56 59 8, v er si on 1 2 Se p 20 13